Single cell at Scale

Our exponential advantage

Why scale up?


Single cell studies are currently limited by expensive technologies or complex experimental workflows. Without the ability to profile high numbers of cells or samples, these studies have limited statistical power to detect true biological signal.  

Scale Bio is on a mission to drastically reduce the complexity of highly powered, robust single cell experiments while simultaneously making single cell more affordable to enable your groundbreaking research.  

The Power of Scale: How to reimagine your single cell experiments

Melanie Masuda
Director of Market Development

 

Reimagine single cell with us

Cell Atlasing

  • Amplify your atlasing efforts with more samples and cells to detect novel and rare cell types  

  • Increase your power to identify disease-specific aberrations

  • With the least hands-on time and lowest cost, get your atlas done with fewer resources  


Biomarker and Drug Discovery 

  • Identify disease-relevant cell types and targets with confidence across more samples

  • High-throughput drug screening is now possible – capture additional compounds, conditions, timepoints – with a high-definition readout 


Large Patient Cohorts  

  • You don't have to choose favorites– run more of your samples for the greatest statistical power

  • Streamline processing by fixing and storing samples until you're ready to run

  • Scale up sample numbers with the confidence of high data quality and reproducibility

  • Incorporate diverse sample sets to enhance representation across ancestral backgrounds, genders, and age groups


Longitudinal and Multi-Site Studies 

  • Collect 10s to 100s of samples across different locations and process together without worrying about batch effects  

  • Power your studies by capturing additional timepoints for a more complete picture 


Functional Genomics 

  • Break through the limitations of legacy single cell technology and test 100s to 1,000s of perturbations in a single experiment  

  • Scale your pooled CRISPR screens to identify novel differentiation pathways, drug targets, resistance mechanisms 


Why Scale Bio?

IMAGE-115542-1727205108250-2

  • Simultaneously process up to hundreds of samples, conditions, or timepoints for ultimate laboratory efficiency 
  • No specialized instruments required 
  • Multiplex samples seamlessly with ScalePlex technology 
  • Trust your results with highly sensitive detection chemistry 
  • Reduce batch effects with simplified sample processing 
  • Achieve cell recovery rates of ≥ 65% 

Advantages of scaling while maintaining cost and gaining efficiency

Cost per sample quantumScale_updated Colorscropped

Scale up while getting the most samples for your budget  

Capture more samples, timepoints, and conditions for making groundbreaking discoveries. Your budget goes further with Scale Bio. Shown are sample numbers with at least 5k cells/sample. 

Figures_100M_Cell_Campaign_Scale up while minimizing hands-on time
Scale up while minimizing hands-on time
 
Scale Bio-generated single cell libraries have similar hands-on time per run as droplet-based technologies that require specialized instrumentation, and less hands-on time than combinatorial indexing methods.  
Figures_100M_Cell_Campaign_Scale up while streamlining lab efficiency
Scale up while streamlining lab efficiency
 
Confidently scale sample numbers with minimal impact on library construction time. *Time includes library prep and sample fixation for 1,000 cells per sample. Droplet technology assumes running 8 channels per chip, and hashing assumes 8 samples per channel. Probe-based droplet technology assumes a 16-plex sample pool per channel.
Figures_100M_Cell_Campaign_Flexible and Easy Workflow
Flexible and easy workflow
 
Timeline for a 50-sample experiment with 10,000 cells per sample. 
Seamless Sample Multiplexing with ScalePlex
Seamless sample multiplexing with ScalePlex
 
Novel oligo-based ScalePlex technology allows you to run 10s-1,000s of samples or conditions in a single run without the need for upfront optimization or individual fixation and washing steps. *Multiplexing capacity of commercially available reagents 

Easily automate the Scale Bio RNA workflow on existing liquid handlers

Reduce hands-on time to less than 3 hours for 96 samples compared to 4.5 hours or more for other automated workflows. *Click on image above to download automation app note

See the data for yourself

MYT1L deficiency

Read the publication from Washington University in St Louis

View publication

Performance analysis

Explore scRNA-seq performance across technologies from Children’s Hospital in Philadelphia

Download poster

Mouse mini tissue atlas

Dive into our application note to unlock the power of multi-tissue single cell RNA sequencing

Download app note

Public datasets

Access representative datasets featuring Scale Bio's single cell library preparation kits

Download datasets

Reducing hands-on time

See the benefits of combining Scale Bio’s scRNA with SPT Labtech’s firefly to simplify the single cell library prep workflow

Download app note

ScalePlex for drug screens

Coming soon - See how ScalePlex enables large-scale drug screening studies using single cell technology

Coming soon

Read our latest blog articles about scaling single cell projects


Access more applications and samples

Application graphic

Proven performance across applications

Profile a variety of fresh or frozen samples types

Ready to scale up your single cell research?

Speak with us to learn how Scale Bio can accelerate your research